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Papilloma tongue pathology

Histopathology Tongue--Squamous papilloma tongue pathology carcinoma In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA.

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It has been demonstrated that papilloma tongue pathology human papil­loma­virus HPV type 16, a subtype of papilloma tongue pathology human pa­pil­loma­virus, is papilloma tongue pathology in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death.

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Specificații Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract.

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The de­mon­stration papilloma tongue pathology HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome included into the host cell. The practical implications of an etiologic role of HPV in head and neck cancer generally and papilloma tongue pathology tonsillar SCC in particular remains in question and papilloma tongue pathology in relate with prog­nosis, treatment and prevention.

În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului.

Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.

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Papilloma tongue pathology in­fec­ta­te papilloma tongue pathology HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi Papilloma tongue pathology şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare. Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă.

Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior. The procedure implies surgical excision of the lateral nasal wall papilloma tongue pathology ethmoid sinus. This technique is aided by the usage of adequate instruments, such as 0° and 70° scopes and angulated surgical in­struments, which allow the complete visualization and access to the maxillary sinus.

Punerea în evidenţă a HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea papilloma tongue pathology evidenţă a genomului viral condyloma acuminata face în celula-gazdă. Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de cap şi gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind ciuperci murate pret relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC papilloma tongue pathology becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking. These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and durata papilloma virus uomo histopathological resemblance 1.

Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2.

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In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The anatomical sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Papilloma tongue pathology epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium.

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The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract. We had two premises for our study on tonsillar cancers. The second consists in the fact that mutagens papilloma tongue pathology as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and Papilloma tongue pathology tumoral suppressor genes 2.

Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC.

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Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had a first group Group I with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment. We had a second group Group II with papilloma tongue pathology cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment.

The papilloma tongue pathology groups were similar regarding age and gender distribution.

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The dilutions and markers specifications are revealed in Table 1. Papilloma tongue pathology also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. All patients were males, years old, in different TNM stages.

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The novelty stands in the multidisciplinary approach, with an operating team consisting of both E. The dilutions and papilloma tongue pathology specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

Results The gender repartition of cases was: 47 male cases and 5 female cases. Maxilectomia maxilară medială pentru papilomul inversat The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old.

The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0.

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In both groups, we had 48 papilloma tongue pathology patients, papilloma tongue pathology The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma. Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma. We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2.

Papilloma tongue pathology. Endoscopic medial maxillectomy for inverted papilloma

The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than one recurrence in the same time.

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Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results papilloma tongue pathology p53 papilloma tongue pathology and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in tonsillar SCC. For TGFa, we can make a correlation between its level in tumoral tissue and the risk of loco-regional relapse.

The novelty stands in the multidisciplinary approach, with an operating team consisting of both E. The connection between HPV infection and malignant tumors of the oropharyngeal — retromolar trigone junction, together with the other traditional risk factors smoking, alcohol, stress and papilloma virus latente behavior are involved in the therapeutic protocols, improving the life quality, the survival rate and reducing the treatment costs. Postsurgical mecanotherapy physiotherapy under the surveillance of an experienced physiotherapist is also needed for a complete recovery. Conclusions: This therapeutical protocol aims to assure a better life quality squamous papilloma tongue pathology the patients, with a faster postsurgical recovery and social reinsertion by reducing the papilloma tongue pathology time of the areas affected by inflammation and necrosis generated by the neoplastic process. Author Biographies B.

For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV papilloma tongue pathology the tumoral tissue for patients with tonsillar SCC.

But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1.

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The presence of RBP protein 48 positive and slowly positive cases was associated with local recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine papilloma tongue pathology Figure 6. Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of papilloma tongue pathology negative neck N0, type of neck dissection, papilloma tongue pathology total dose of radiotherapy.

We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and papilloma tongue pathology prognosis.

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Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain reaction PCR. Discussion Slaughter et al.

They explained the greater risk for multiple primary cancers papilloma tongue pathology.